REACTION OF JORDAN CATION [CP2ZRCH3(THF)](-DERIVED ISOCYANATES - A FIRST SYNTHETIC ROUTE TO OLIGOPEPTIDE-MODIFIED GROUP-4 BENT METALLOCENE CATION SYSTEMS() WITH AMINO ACID)

Citation
M. Oberhoff et al., REACTION OF JORDAN CATION [CP2ZRCH3(THF)](-DERIVED ISOCYANATES - A FIRST SYNTHETIC ROUTE TO OLIGOPEPTIDE-MODIFIED GROUP-4 BENT METALLOCENE CATION SYSTEMS() WITH AMINO ACID), Chemistry, 3(9), 1997, pp. 1521-1525
Citations number
100
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Chemistry
Journal title
Chemistry → ACNP
ISSN journal
0947-6539
Volume
3
Issue
9
Year of publication
1997
Pages
1521 - 1525
Database
ISI
SICI code
0947-6539(1997)3:9<1521:ROJC[I>2.0.ZU;2-L
Abstract
The organometallic cation [Cp2ZrCH3 (thf)](+), employed as the tetra p henylborate salt (1), reacts cleanly in 1:1 stoichiometry with the iso cyanates 2 derived from valine methyl ester or valylvaline methyl este r, respectively. In each case addition of the Zr-CH3 group to the isoc yanate sp-carbon center is observed with formation of a functionalized zirconocene cation derivative containing a chelating N-metallated N-a cetylvaline methyl ester (3a) or N-acetylvalylvaline methyl ester (3b) moiety, respectively, coordinated in the bent metallocene sigma-ligan d plane. The spectroscopic data of 3, supported by an X-ray crystal st ructure analysis of the zirconated dipeptide derivative 3b, have revea led the presence of chelating (eta(1)-O: eta(1)-N)-coordination of the terminal N-acetyl groups in addition to a Zr-O=C interaction with the adjacent valyl amido group.