ELECTROSPRAY MASS-SPECTROMETRY OF POLY(PROPYLENE IMINE) DENDRIMERS - THE ISSUE OF DENDRITIC PURITY OR POLYDISPERSITY

Citation
Jc. Hummelen et al., ELECTROSPRAY MASS-SPECTROMETRY OF POLY(PROPYLENE IMINE) DENDRIMERS - THE ISSUE OF DENDRITIC PURITY OR POLYDISPERSITY, Chemistry, 3(9), 1997, pp. 1489-1493
Citations number
31
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry
Journal title
Chemistry → ACNP
ISSN journal
0947-6539
Volume
3
Issue
9
Year of publication
1997
Pages
1489 - 1493
Database
ISI
SICI code
0947-6539(1997)3:9<1489:EMOPID>2.0.ZU;2-5
Abstract
Electrospray mass spectrometry (ESI-MS) is used to analyze in detail t he structure of the first five generations of the poly(propylene imine ) dendrimers with 4-64 end groups, Although the reaction sequence to p repare these dendrimers is highly optimized, an accumulation of statis tical defects is observed at higher generations. A simple statistical simulation allows the assignment of all peaks in deconvoluted spectrum and the determination of yields for each side reaction in the formati on of each generation. The fifth generation of the poly(propylene imin e) dendrimer containing amine end groups, which is formed after 248 co nsecutive reaction steps, possesses a dendritic purity of approx. 20%, which corresponds to a polydispersity of approximately 1.002. The def ects in the divergent growth patterns of dendrimers are compared to th ose observed in the Merrifield synthesis of polypeptides.