Shell-crosslinked knedels are nanometer-sized (5-200 nm diameters), am
phiphilic core-shell spheres that are prepared by the self-assembly of
amphiphilic block copolymers into polymer micelles, followed by cross
linking of side chain functionalities along the block composing the sh
ell of the polymer micelles. Such structures resemble dendrimers in th
e basic structural components, and have the advantages of a rapid synt
hetic approach and the production of larger and broader size ranges.