BETA-CAROTENE INTAKE AND RISK OF NONFATAL ACUTE MYOCARDIAL-INFARCTIONIN WOMEN

Citation
A. Tavani et al., BETA-CAROTENE INTAKE AND RISK OF NONFATAL ACUTE MYOCARDIAL-INFARCTIONIN WOMEN, European journal of epidemiology, 13(6), 1997, pp. 631-637
Citations number
41
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Public, Environmental & Occupation Heath
ISSN journal
0393-2990
Volume
13
Issue
6
Year of publication
1997
Pages
631 - 637
Database
ISI
SICI code
0393-2990(1997)13:6<631:BIARON>2.0.ZU;2-V
Abstract
There are indications that beta-carotene, but not pre-formed vitamin A , is protective on the risk of acute myocardial infarction (AMI). The relationship between nonfatal AMI and the intake of beta-carotene and retinol was investigated in a case-control study conducted between 198 3 and 1992 in northern Italy on 433 women with nonfatal AMI and 869 co ntrols in hospital for acute, non-cardiovascular, non-neoplastic, non- digestive, non-hormone related conditions. Odds ratios (OR), with thei r 95% confidence intervals (CI), were computed by unconditional multip le logistic regression analysis, including terms for age, education, b ody mass index, smoking, alcohol and coffee drinking, menopausal statu s, hormone replacement therapy and history of diabetes, hypertension a nd hyperlipidemia. The risk of AMI was inversely related to beta-carot ene intake, with an OR of 0.5 (95% CI: 0.3 to 0.8) for the highest qui ntile of intake compared to the fewest (chi(2) trend = 10.53, p < 0.01 ). Retinol intake was not associated with AMI, with an OR of 0.9 (95% CI: 0.6 to 1.3) for the highest quintile of intake compared to the low est. Analysis in separate strata of covariates indicated that the inve rse association of beta-carotene intake with risk of AMI was appreciab ly stronger in younger, lean women with no history of diabetes or hype rtension, and in current smokers. The results of this study indicate t hat the risk of nonfatal AMI in women is inversely related to intake o f beta-carotene containing foods, but not foods containing retinol.