MASS-SPECTROMETRIC INVESTIGATION OF SOME ALPHA-TRIFLUOROMETHYL-ALPHA-AMINO ACIDS

Citation
J. Rimlinger et al., MASS-SPECTROMETRIC INVESTIGATION OF SOME ALPHA-TRIFLUOROMETHYL-ALPHA-AMINO ACIDS, Journal of mass spectrometry., 32(9), 1997, pp. 1002-1007
Citations number
24
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry Inorganic & Nuclear",Spectroscopy,Biophysics
ISSN journal
1076-5174
Volume
32
Issue
9
Year of publication
1997
Pages
1002 - 1007
Database
ISI
SICI code
1076-5174(1997)32:9<1002:MIOSA>2.0.ZU;2-U
Abstract
he fast atom bombardment-induced mass spectrometric behaviour of four fluorinated alpha-amino acids was studied in detail with the aid of me tastable ion studies anal accurate mass measurements. Comparison with that behaviour of unfluorinated analogues suggests that the presence o f fluorin makes the carbonylic oxygen the mast prone to protonation, T his hypothesis was confirmed by AM1 semiempirical calculations which i ndicate that the carbonylic oxygen of the carboxyl group exhibits, in the case of fluorinated components only, the highest proton affinity. (C) 1997 by John Wiley & Sons, Ltd.