LOCAL OPIATE WITHDRAWAL IN LOCUS-COERULEUS IN-VIVO

Citation
G. Astonjones et al., LOCAL OPIATE WITHDRAWAL IN LOCUS-COERULEUS IN-VIVO, Brain research, 765(2), 1997, pp. 331-336
Citations number
17
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences
Journal title
ISSN journal
0006-8993
Volume
765
Issue
2
Year of publication
1997
Pages
331 - 336
Database
ISI
SICI code
0006-8993(1997)765:2<331:LOWILI>2.0.ZU;2-X
Abstract
Hyperactivity of noradrenergic locus coeruleus (LC) neurons following withdrawal from chronic opiates has been implicated in the opiate with drawal syndrome. Here, we report that local withdrawal induced in vivo by microinfusion of an opiate antagonist into the LC of morphine-depe ndent rats marginally, but significantly, activated LC neurons above t he level obtained with local naloxone microinfusion in naive rats. Thi s local withdrawal response contributes a significant fraction (simila r to 19%) of the total LC hyperactivity induced by systemic naloxone. (C) 1997 Elsevier Science B.V.