POSSIBLE REGULATION OF INTRACRANIAL-PRESSURE BY HUMAN ATRIAL-NATRIURETIC-PEPTIDE IN CEREBROSPINAL-FLUID

Citation
H. Yamasaki et al., POSSIBLE REGULATION OF INTRACRANIAL-PRESSURE BY HUMAN ATRIAL-NATRIURETIC-PEPTIDE IN CEREBROSPINAL-FLUID, European neurology, 38(2), 1997, pp. 88-93
Citations number
15
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Clinical Neurology",Neurosciences
Journal title
ISSN journal
0014-3022
Volume
38
Issue
2
Year of publication
1997
Pages
88 - 93
Database
ISI
SICI code
0014-3022(1997)38:2<88:PROIBH>2.0.ZU;2-L
Abstract
To clarify the function of human atrial natriuretic peptide (hANP) in the cerebrospinal fluid (CSF), we examined hANP levels in the CSF of p atients with various neurological diseases. The subjects were 16 contr ols without neurological disease and 45 patients with neurological dis ease. The 45 patients with neurological disease were divided into a gr oup of 15 patients with intracranial hypertension (IH) and a group of 30 patients with normal pressure (NP). hANP in both CSF (1-hANP) and s erum (s-hANP) was measured by RIA. Patients with IH were followed up. We analyzed correlations between 1-hANP and other parameters of CSF. I ncrease in concentration of 1-hANP was positively correlated with intr acranial pressure (ICP; r = 0.72; p < 0.01), but not with other CSF pa rameters or with s-hANP. The concentration of 1-hANP appeared to be in creased especially over a threshold value of ICP. In a followup study of patients with IH, changes in 1-hANP paralleled changes in ICP in ev ery case (r = 0.79; p < 0.01). Our findings strongly suggest that 1-hA NP plays an important role in the regulation of ICP in humans.