OVERSHOOT OF ETHANOL IN THE BLOOD AFTER DRINKING ON AN EMPTY STOMACH

Citation
Rg. Hahn et al., OVERSHOOT OF ETHANOL IN THE BLOOD AFTER DRINKING ON AN EMPTY STOMACH, Alcohol and alcoholism, 32(4), 1997, pp. 501-505
Citations number
12
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Substance Abuse
Journal title
ISSN journal
0735-0414
Volume
32
Issue
4
Year of publication
1997
Pages
501 - 505
Database
ISI
SICI code
0735-0414(1997)32:4<501:OOEITB>2.0.ZU;2-6
Abstract
The time required for ethanol to distribute between the systemic circu lation and the rest of the body water results in an 'overshoot' of the blood-alcohol concentration (BAG) during the first 30 min after intra venous infusion. To investigate whether a similar distribution phenome non occurs when ethanol is given by the oral route, we compared BACs a fter intravenous infusion and oral intake under strictly controlled co nditions by giving a 0.4 g/kg dose of ethanol over 15 min to six fasti ng female volunteers. The results show an 'overshoot' in three volunte ers who had the shortest time to BAC(max), which indicates rapid absor ption, and the time-course was similar to the distribution phase seen during the intravenous experiments. We conclude that BAC is sometimes higher than expected shortly after alcohol has been ingested rapidly. This finding can probably be explained by the fact that ethanol is dis tributed more slowly throughout the total body water than it is absorb ed from the gut.