A NOVEL VARIANT OF STAPHYLOKINASE GENE FROM STAPHYLOCOCCUS-AUREUS ATCC-29213

Citation
Sh. Kim et al., A NOVEL VARIANT OF STAPHYLOKINASE GENE FROM STAPHYLOCOCCUS-AUREUS ATCC-29213, Thrombosis research, 87(4), 1997, pp. 387-395
Citations number
13
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Hematology,"Peripheal Vascular Diseas
Journal title
ISSN journal
0049-3848
Volume
87
Issue
4
Year of publication
1997
Pages
387 - 395
Database
ISI
SICI code
0049-3848(1997)87:4<387:ANVOSG>2.0.ZU;2-J
Abstract
The processes of hemostasis and thrombolysis are elegantly regulated i n order to ensure normal functions of vascular system. A search for ne w plasminogen activators as thrombolytic agents has been carried out f or the purpose of clinical applications to modulate thrombolytic proce sses. In the current work, several strains and clinical isolates of St aphylococcus aureus were screened for the fibrinolytic activity. The D NA sequences of staphylokinase gene in the strains expressing 15 kDa p rotein with staphylokinase activity were determined and subsequently c ompared with three known staphylokinase gene sequences. From the seque nce comparison a new variant of staphylokinase gene has been identifie d in ATCC 29213 strain. The gene product needs to be further character ized and tested for the therapeutic potential. (C) 1997 Elsevier Scien ce Ltd.