Indirect evidence that intestinal bile salt absorption in rats and hamsters is under positive feedback control

Citation
J. Scheibner et al., Indirect evidence that intestinal bile salt absorption in rats and hamsters is under positive feedback control, Z GASTROENT, 39(11), 2001, pp. 929
Citations number
38
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Gastroenerology and Hepatology
Journal title
ZEITSCHRIFT FUR GASTROENTEROLOGIE
ISSN journal
0044-2771 → ACNP
Volume
39
Issue
11
Year of publication
2001
Database
ISI
SICI code
0044-2771(200111)39:11<929:IETIBS>2.0.ZU;2-5
Abstract
Bile salts are reabsorbed from the intestine by active and passive transpor t mechanisms with great efficacy. Conflicting data do not allow to judge fo r certainty whether bile salt absorption is under negative or positive feed back control. To address this issue, we analyzed bile salt absorption in vi vo along the entire intestinal tract of rats and hamsters that received int raduodenal bile salt infusions for 54 h following interruption of the enter ohepatic circulation. Taurocholate absorption in rats was complete, even wh en un physiologically high concentrations of taurocholate were given. The c ombined infusion of taurocholate together with potent inhibitors of bile sa lt synthesis such as deoxycholate, taurodeoxycholate or taurochenodeoxychol ate, failed to inhibit bile salt absorption. In the hamster, taurochenodeox ycholate and taurocholate absorption was complete and could not be inhibite d when given in supraphysiological concentrations. Finally, taurocholate ab sorption was not impaired when deoxycholic acid was infused. These results provide indirect evidence that bile salt absorption is under positive feedb ack control regulated by luminal bile salt concentrations.