Indirect evidence that intestinal bile salt absorption in rats and hamsters is under positive feedback control

Scheibner, J Stange, EF Fuchs, M

J. Scheibner et al., Indirect evidence that intestinal bile salt absorption in rats and hamsters is under positive feedback control, Z GASTROENT, 39(11), 2001, pp. 929

38

INGLESE

Article

Gastroenerology and Hepatology

ZEITSCHRIFT FUR GASTROENTEROLOGIE

0044-2771 → ACNP

39

11

2001

ISI

0044-2771(200111)39:11<929:IETIBS>2.0.ZU;2-5

Bile salts are reabsorbed from the intestine by active and passive transpor t mechanisms with great efficacy. Conflicting data do not allow to judge fo r certainty whether bile salt absorption is under negative or positive feed back control. To address this issue, we analyzed bile salt absorption in vi vo along the entire intestinal tract of rats and hamsters that received int raduodenal bile salt infusions for 54 h following interruption of the enter ohepatic circulation. Taurocholate absorption in rats was complete, even wh en un physiologically high concentrations of taurocholate were given. The c ombined infusion of taurocholate together with potent inhibitors of bile sa lt synthesis such as deoxycholate, taurodeoxycholate or taurochenodeoxychol ate, failed to inhibit bile salt absorption. In the hamster, taurochenodeox ycholate and taurocholate absorption was complete and could not be inhibite d when given in supraphysiological concentrations. Finally, taurocholate ab sorption was not impaired when deoxycholic acid was infused. These results provide indirect evidence that bile salt absorption is under positive feedb ack control regulated by luminal bile salt concentrations.