The use of micro-thermal analysis as a means of in situ characterisation of a pharmaceutical tablet coat

Citation
Pg. Royall et al., The use of micro-thermal analysis as a means of in situ characterisation of a pharmaceutical tablet coat, THERMOC ACT, 380(2), 2001, pp. 165-173
Citations number
19
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Spectroscopy /Instrumentation/Analytical Sciences
Journal title
THERMOCHIMICA ACTA
ISSN journal
0040-6031 → ACNP
Volume
380
Issue
2
Year of publication
2001
Pages
165 - 173
Database
ISI
SICI code
0040-6031(200112)380:2<165:TUOMAA>2.0.ZU;2-P
Abstract
The technique of micro-thermal analysis (MTA) has been applied to a commerc ial sugar coated ibuprofen tablet in order to identify the ability of the m ethod to differentiate between the coat and the tablet core and to characte rise the thermal properties of both components using localised thermal anal ysis. Thermal conductivity measurements in conjunction with intensity histo gram analysis indicated that differentiation across the coat/core interface was possible, with a bimodal distribution of pixel intensities correspondi ng to thermal conductivity noted. Localised thermal analysis studies indica ted that the bulk response was dominated by the incorporated ibuprofen, wit h a discontinuity seen at ca. 70-80 degreesC, corresponding to the publishe d melting point of the drug. The coat showed a discontinuity at ca. 220 deg reesC that may be reasonably ascribed to the melting process. It was also n oted that the coat showed a small discontinuity at a temperature correspond ing to the melting of ibuprofen. In summary, the technique was shown to be capable of identifying the core/coat interface using thermal conductivity m easurements, while localised thermal analysis experiments enable the operat or to perform thermal analysis experiments on the individual components in situ. (C) 2001 Elsevier Science B.V. All rights reserved.