A possible association between carpal tunnel syndrome and HIV infection has
been suggested only once until now. Two patients with HIV infection are de
scribed who presented confirmed carpal tunnel syndrome while on prolonged p
rotease inhibitor-containing highly active antiretroviral therapy (HAART).
Their disease course and long-term outcome after medical and/or surgical in
terventions is presented and discussed according to available evidence from
the literature. In our patients, carpal tunnel syndrome occurred in appare
nt absence of all presumed risk factors of this disease and metabolic abnor
malities potentially related to HIV protease inhibitor administration.