Effect of cyclic plasma perfusion on apoptosis regulatory proteins in primary tumors of VX2-carcinoma-bearing rabbits

Citation
O. Ishiko et al., Effect of cyclic plasma perfusion on apoptosis regulatory proteins in primary tumors of VX2-carcinoma-bearing rabbits, INT J ONCOL, 19(2), 2001, pp. 325-329
Citations number
27
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
INTERNATIONAL JOURNAL OF ONCOLOGY
ISSN journal
1019-6439 → ACNP
Volume
19
Issue
2
Year of publication
2001
Pages
325 - 329
Database
ISI
SICI code
1019-6439(200108)19:2<325:EOCPPO>2.0.ZU;2-2
Abstract
Although the mechanism of cancer cachexia is unknown, in previous studies w e reported that cyclic plasma perfusion through non-coated charcoal was eff ective in preventing cancer cachexia. In the present study we investigated the effect of cyclic plasma perfusion on VX2 carcinoma. Sixteen tumor-beari ng rabbits were divided into two groups: i) a group subjected to cyclic pla sma perfusion (n=8, group PP) and ii) a group subjected to sham-perfusion ( n=8, group SP), and changes in body weight, tumor size, and morphological f indings were investigated. Body weight loss and tumor growth were significa ntly suppressed in group PP. The tumor cells in group PP showed apoptosis a nd a high Bax/Bcl-2 ratio, and the survival rate was significantly higher t han in group SP. These results suggest that cyclic plasma perfusion is effe ctive not only in preventing cancer cachexia but in suppressing tumor growt h and improving outcome.