M. Satoh et al., Inhibitory effects of fullerene C-60 derivatives on endothelium-derived relaxation in rabbit thoracic aorta, FUL SCI TEC, 9(2), 2001, pp. 141-151
Inhibitory effects of newly synthesized fullerene C-60 derivatives I (C-60-
bis(N,N-dimethylpyrrolidinium iodide)), 2 (C-60-proline-N-acetic acid) and
3 (C-60-ethylenediamine-N, N'-diacetic acid) on acetylcholine-induced relax
ation in endothelium-intact rabbit thoracic aorta precontracted by phenylep
hrine (10(-6) M) were studied. Fullerene C-60 derivative 1 (3 x 10(-6) M),
2 (10(-5) M) and 3 (10(-5) M) reduced the maximum amplitude of the acetylch
oline-induced relaxation without significantly changing the pD(2) values ob
tained from the concentration - response curves. In the presence of fullere
ne C-60 derivative 1 (10(-5) M) the acetylcholine-induced relaxation was el
iminated and an acetylcholine-induced contraction was observed. These resul
ts suggest that fullerene C-60 derivative 1 strongly inhibits endothelium (
nitric oxide)-dependent acetylcholine-induced relaxation in thoracic aorta
of rabbit.