Inhibitory effects of fullerene C-60 derivatives on endothelium-derived relaxation in rabbit thoracic aorta

Citation
M. Satoh et al., Inhibitory effects of fullerene C-60 derivatives on endothelium-derived relaxation in rabbit thoracic aorta, FUL SCI TEC, 9(2), 2001, pp. 141-151
Citations number
26
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Physical Chemistry/Chemical Physics
Journal title
FULLERENE SCIENCE AND TECHNOLOGY
ISSN journal
1064-122X → ACNP
Volume
9
Issue
2
Year of publication
2001
Pages
141 - 151
Database
ISI
SICI code
1064-122X(2001)9:2<141:IEOFCD>2.0.ZU;2-I
Abstract
Inhibitory effects of newly synthesized fullerene C-60 derivatives I (C-60- bis(N,N-dimethylpyrrolidinium iodide)), 2 (C-60-proline-N-acetic acid) and 3 (C-60-ethylenediamine-N, N'-diacetic acid) on acetylcholine-induced relax ation in endothelium-intact rabbit thoracic aorta precontracted by phenylep hrine (10(-6) M) were studied. Fullerene C-60 derivative 1 (3 x 10(-6) M), 2 (10(-5) M) and 3 (10(-5) M) reduced the maximum amplitude of the acetylch oline-induced relaxation without significantly changing the pD(2) values ob tained from the concentration - response curves. In the presence of fullere ne C-60 derivative 1 (10(-5) M) the acetylcholine-induced relaxation was el iminated and an acetylcholine-induced contraction was observed. These resul ts suggest that fullerene C-60 derivative 1 strongly inhibits endothelium ( nitric oxide)-dependent acetylcholine-induced relaxation in thoracic aorta of rabbit.