Mitoxantrone and paclitaxel combination chemotherapy in metastatic breast cancer

Citation
J. Harvey et al., Mitoxantrone and paclitaxel combination chemotherapy in metastatic breast cancer, CANCER INV, 19(3), 2001, pp. 225-233
Citations number
28
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Oncology,"Onconogenesis & Cancer Research
Journal title
CANCER INVESTIGATION
ISSN journal
0735-7907 → ACNP
Volume
19
Issue
3
Year of publication
2001
Pages
225 - 233
Database
ISI
SICI code
0735-7907(2001)19:3<225:MAPCCI>2.0.ZU;2-#
Abstract
This study evaluated mitoxantrone and paclitaxel combination chemotherapy i n the treatment of patients with metastatic breast cancer. Thirty-seven pat ients who had developed progressive disease after prior chemotherapy were t reated with mitoxantrone (14 mg/m(2)) and paclitaxel (150 mg/m(2)) every 21 days for a maximum of six cycles. The most frequent grade 3 or 4 nonhemato logical toxicities were fever and nausea. Grade 4 neutropenia occurred in 7 1% of patients. Cardiotoxicity occurred in 2 patients, both of whom had pre viously received doxorubicin. Objective response was achieved in 35% of pat ients (5% complete response and 30% partial response) and 41% had stable di sease. Median time to disease progression and median survival were 6 and 12 months, respectively. The percent of patients with an objective response w as not different for those who had received prior doxorubicin or had chemot herapy in the preceding 6 months. This regimen appears to be effective and well tolerated as salvage therapy and merits further evaluation.