Design and synthesis of a highly selective EP2-receptor agonist

Citation
K. Tani et al., Design and synthesis of a highly selective EP2-receptor agonist, BIOORG MED, 11(15), 2001, pp. 2025-2028
Citations number
14
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960-894X → ACNP
Volume
11
Issue
15
Year of publication
2001
Pages
2025 - 2028
Database
ISI
SICI code
0960-894X(20010806)11:15<2025:DASOAH>2.0.ZU;2-Y
Abstract
EP2-receptor selective agonist 3 was identified by the structural hybridiza tion of butaprost 1a and PGE(2) 2a. Based on this information, a chemically more stabilized 4 was discovered as another highly selective EP2-receptor agonist, iv administration of which to anesthetized rats suppressed uterine motility, while PGE(2) 2a stimulated uterine motility. (C) 2001 Elsevier S cience Ltd. All rights reserved.