EP2-receptor selective agonist 3 was identified by the structural hybridiza
tion of butaprost 1a and PGE(2) 2a. Based on this information, a chemically
more stabilized 4 was discovered as another highly selective EP2-receptor
agonist, iv administration of which to anesthetized rats suppressed uterine
motility, while PGE(2) 2a stimulated uterine motility. (C) 2001 Elsevier S
cience Ltd. All rights reserved.