Granzyme B and TIA-1 expression in chronic and acute on chronic renal allograft rejection

Citation
Sw. Hong et al., Granzyme B and TIA-1 expression in chronic and acute on chronic renal allograft rejection, YONSEI MED, 42(3), 2001, pp. 285-290
Citations number
28
Language
INGLESE
art.tipo
Article
Categorie Soggetti
General & Internal Medicine
Journal title
YONSEI MEDICAL JOURNAL
ISSN journal
0513-5796 → ACNP
Volume
42
Issue
3
Year of publication
2001
Pages
285 - 290
Database
ISI
SICI code
0513-5796(200106)42:3<285:GBATEI>2.0.ZU;2-X
Abstract
Although active inflammation may be deleterious and indicate immunologic ac tivation in chronically rejected grafts, the underlying mechanism of tissue destruction has been little studied. Twenty-four cases of chronic rejectio n (CR) with or without acute rejection (AR) were stained with antibodies ag ainst CD3, CD8, CD68, granzyme B and TIA-1, and the number of positive cell s were counted. Eleven cases of AR served as controls. The number of CD3 an d CD8 positive cells increased in the acute on CR group compared to the CR group. About a half of CD3 positive T cells were CD8 positive in both group s, however, the proportion of TIA-1 or granzyme B positive cells was higher in the acute on CR group. The numbers of CD3, CD68, granzyme B and TlA-1 p ositive cells were higher in the AR group than the acute on CR group, howev er, no significant difference was found between the two groups. Serum creat inine level and proteinuria at the time of biopsy and the percentages of la te onset AR and graft failure rate were higher in the acute on CR group tha n the CR group. Summarizing, these results suggest that infiltration of act ivated T cells containing cytotoxic granules plays a role in graft destruct ion in acute on CR.