Hypnotic action of melatonin during daytime administration and its comparison with triazolam

Citation
T. Satomura et al., Hypnotic action of melatonin during daytime administration and its comparison with triazolam, PSY CLIN N, 55(3), 2001, pp. 303-304
Citations number
3
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Clinical Psycology & Psychiatry
Journal title
PSYCHIATRY AND CLINICAL NEUROSCIENCES
ISSN journal
1323-1316 → ACNP
Volume
55
Issue
3
Year of publication
2001
Pages
303 - 304
Database
ISI
SICI code
1323-1316(200106)55:3<303:HAOMDD>2.0.ZU;2-A
Abstract
The present study was conducted to assess hypnotic action, effects on recta l temperature and dose dependency by daytime administration of exogenous me latonin (MLT) at 1 mg, 3 mg or 6 mg to subjects consisting of seven healthy juvenile adults. As a result, exogenous MLT significantly increased total sleep time and sleep efficiency, and MLT 6mg was observed to demonstrate hy pnotic effects that were nearly equal to those of triazolam at 0.125 mg. Re ctal temperature was significantly decreased at MLT 1mg and 3 mg. there wer e no significant differences observed in the hypothermic effects at MLT 6mg . These results indicate that exogenous MLT had dose-dependent hypnotic act ion on daytime sleep, and it is possible to consider that this hypnotic act ion was based on a direct-acting mechanism.