Narcoleptic canines display periodic leg movements during sleep

Citation
M. Okura et al., Narcoleptic canines display periodic leg movements during sleep, PSY CLIN N, 55(3), 2001, pp. 243-244
Citations number
6
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Clinical Psycology & Psychiatry
Journal title
PSYCHIATRY AND CLINICAL NEUROSCIENCES
ISSN journal
1323-1316 → ACNP
Volume
55
Issue
3
Year of publication
2001
Pages
243 - 244
Database
ISI
SICI code
1323-1316(200106)55:3<243:NCDPLM>2.0.ZU;2-S
Abstract
Periodic leg movements during sleep (PLMS) is a high prevalent sleep disord er of unknown etiology. The disease is pharmacologically treated with dopam inergic agonists (i.e. D2/D3 agonists) and opiates. Periodic leg movements during sleep often occur in narcoleptic patients. We observed that narcolep tic canines, like narcoleptic humans, also exhibit jerky, unilateral or bil ateral slow leg movements during sleep. The movements in dogs are character ized by repetitive dorsiflexions of the ankle, lasting 0.5-1.5 s, and occur at regular intervals of 3-20 s, thus showing similarities to PLMS in human s. The observation that D2/D3 agonists aggravate cataplexy in narcoleptic d ogs suggests that altered dopaminergic regulation in canine narcolepsy may play a critical role in both cataplexy and PLMS. Our canines may therefore be an invaluable resource in PLMS research.