Effects of isoflurane and ketamine on sleep in rabbits

Citation
S. Takahashi et al., Effects of isoflurane and ketamine on sleep in rabbits, PSY CLIN N, 55(3), 2001, pp. 239-240
Citations number
4
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Clinical Psycology & Psychiatry
Journal title
PSYCHIATRY AND CLINICAL NEUROSCIENCES
ISSN journal
1323-1316 → ACNP
Volume
55
Issue
3
Year of publication
2001
Pages
239 - 240
Database
ISI
SICI code
1323-1316(200106)55:3<239:EOIAKO>2.0.ZU;2-X
Abstract
The postoperative sleep disturbance (POSD) is characterized by reduction of sleep after surgical operation. However, its mechanism is not well known. Therefore, we hypothesized that anesthetics could contribute to the POSD, a nd studied the effects of isoflurane and ketamine on sleep in rabbits. Rabb it sleep was measured for 21 h after isoflurane exposure or intravenous inj ection of ketamine. Non-rapid eve movement sleep (NREMS) was decreased afte r isoflurane anesthesia. In contrast, ketamine anesthesia significantly enh anced NREMS. Both anesthetics did not affect rapid eye movement sleep. Thes e results suggest that isoflurane may contribute to the POSD, but ketamine may decrease the POSD.