Toward the creation of NMR databases in chiral solvents for assignments ofrelative and absolute stereochemistry: Proof of concept

Citation
Y. Kobayashi et al., Toward the creation of NMR databases in chiral solvents for assignments ofrelative and absolute stereochemistry: Proof of concept, ORG LETT, 3(14), 2001, pp. 2245-2248
Citations number
17
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
1523-7060 → ACNP
Volume
3
Issue
14
Year of publication
2001
Pages
2245 - 2248
Database
ISI
SICI code
1523-7060(20010712)3:14<2245:TTCOND>2.0.ZU;2-9
Abstract
[GRAPHICS] An NMR database approach in a chiral solvent allows us to predict both rela tive and absolute stereochemistry of an unknown compound without degradatio n and/or derivatization, N,alpha -Dimethylbenzylamine (DMBA) is a suitable solvent for this purpose. Using the C.5-C.10 portion of oasomycin A, the fe asibility and reliability of this approach is demonstrated.