An NMR database approach in a chiral solvent allows us to predict both rela
tive and absolute stereochemistry of an unknown compound without degradatio
n and/or derivatization, N,alpha -Dimethylbenzylamine (DMBA) is a suitable
solvent for this purpose. Using the C.5-C.10 portion of oasomycin A, the fe
asibility and reliability of this approach is demonstrated.