Enantioselective biotransformations of racemic 2-aryl-3-methylbutyronitriles using Rhodococcus sp AJ270

Citation
Mx. Wang et al., Enantioselective biotransformations of racemic 2-aryl-3-methylbutyronitriles using Rhodococcus sp AJ270, J MOL CAT B, 14(4-6), 2001, pp. 77-83
Citations number
37
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Physical Chemistry/Chemical Physics
Journal title
JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC
ISSN journal
1381-1177 → ACNP
Volume
14
Issue
4-6
Year of publication
2001
Pages
77 - 83
Database
ISI
SICI code
1381-1177(20010706)14:4-6<77:EBOR2>2.0.ZU;2-P
Abstract
Rhodococcus sp. AJ270 is a useful biocatalyst for the synthesis of some ena ntiopure S-(+)-2-aryl-3-methylbutyric acids and R-(+)-2-aryl-3-methylbutyra mides from the hydrolysis of 2-aryl-3-methylbutyronitriles under mild condi tions. The nitrile-hydrolyzing enzymes involved in this novel microorganism are very sensitive to the steric effect of the para-substituent on the aro matic ring. While the nitrile hydratase displays a low S-enantioselectivity against nitriles, the amidase has a strict S-enantioselectivity against 2- aryl-3-methylbutyramides. (C) 2001 Elsevier Science B.V. All rights reserve d.