Quantitative retention activity relationship of quinolones using micellar liquid chromatography

Citation
Dh. Kim et al., Quantitative retention activity relationship of quinolones using micellar liquid chromatography, J LIQ CHR R, 24(9), 2001, pp. 1309-1322
Citations number
13
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry & Analysis","Spectroscopy /Instrumentation/Analytical Sciences
Journal title
JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES
ISSN journal
1082-6076 → ACNP
Volume
24
Issue
9
Year of publication
2001
Pages
1309 - 1322
Database
ISI
SICI code
1082-6076(2001)24:9<1309:QRAROQ>2.0.ZU;2-A
Abstract
This study investigated the quantitative retention activity relationship of quinolones by using micellar liquid chromatography. Using different types of surfactants, retention behaviors of quinolones were studied. Based on th e retention data, obtained from different micellar conditions, a quantitati ve retention-activity relationship was applied to the representative bacter ia, E. coli, P. aeruginosa, and S. aureus. In the case of P. aeruginosa, a linear relationship was observed fur CTAB, and SDS. On the other hand no re lationship was found for any kinds of bacteria, when the retention data, ob tained from Brij 35, and SB 3-10 were applied. This study also matches thes e relationships to the quinolone active site, DNA gyrase, and explains its action mechanism.