Correlations between motor persistence and plasma levels in methylphenidate-treated boys with ADHD

Citation
Ll. Greenhill et al., Correlations between motor persistence and plasma levels in methylphenidate-treated boys with ADHD, IN J NEUROP, 4(2), 2001, pp. 207-215
Citations number
54
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurology
Journal title
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
ISSN journal
1461-1457 → ACNP
Volume
4
Issue
2
Year of publication
2001
Pages
207 - 215
Database
ISI
SICI code
1461-1457(200106)4:2<207:CBMPAP>2.0.ZU;2-6
Abstract
Following a 0.9 mg/kg methylphenidate loading dose, serial plasma level det erminations, self-scored mood ratings, and measures of motor persistence we re gathered on eight previously unmedicated boys with attention deficit dis order with hyperactivity (ADHD) during a 9-h period. The measures were repe ated using the same loading dose after 6 months of maintenance treatment wi th methylphenidate (1.3 mg/kg.d). Kinetic-dynamic modelling suggests invers e correlative relationships between motor performance errors and plasma lev els. Pharmacokinetic parameters did not change between acute and maintenanc e drug treatment phases, and there was no evidence of long-term tolerance.