Are mast cells MASTers in HIV-1 infection?

Citation
G. Marone et al., Are mast cells MASTers in HIV-1 infection?, INT A AL IM, 125(2), 2001, pp. 89-95
Citations number
83
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Immunology
Journal title
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
ISSN journal
1018-2438 → ACNP
Volume
125
Issue
2
Year of publication
2001
Pages
89 - 95
Database
ISI
SICI code
1018-2438(200106)125:2<89:AMCMIH>2.0.ZU;2-#
Abstract
HIV-1 gp120 interacts with IgE V(H)3(+) on the surface of human basophils a nd mast cells (Fc epsilon RI+ cells), acting as a viral immunoglobulin supe rantigen, gp120 from different clades induces mediator release from Fc epsi lon RI+ cells. gp120 also induces IL-4 and IL-13 synthesis in human basophi ls. The chemokine receptors CCR3 and CXCR4, which are coreceptors of HIV-1 infection, are expressed by human Fc epsilon RI+ cells. HIV-1 Tat protein i s a potent chemoattractant for basophils and lung mast cells, interacting w ith CCR3. Incubation of basophils with Tat protein upregulates the surface expression of the CCR3 receptor. There is evidence that human Fc epsilon RI + cells could be infected in vitro by M-tropic HIV-1 strains. Copyright (C) 2001 S. Karger AG, Basel.