Expression of the alpha v integrin adhesion molecule during development ofpreimplantation human embryos

Citation
Ak. Dubey et al., Expression of the alpha v integrin adhesion molecule during development ofpreimplantation human embryos, FERT STERIL, 76(1), 2001, pp. 153-156
Citations number
15
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Reproductive Medicine","da verificare
Journal title
FERTILITY AND STERILITY
ISSN journal
0015-0282 → ACNP
Volume
76
Issue
1
Year of publication
2001
Pages
153 - 156
Database
ISI
SICI code
0015-0282(200107)76:1<153:EOTAVI>2.0.ZU;2-E
Abstract
Objective: To investigate the expression of cry integrin in developing huma n embryos. Design: Observational study. Setting: University medical center. Patient(s): Women undergoing IVF cycles . Intervention(s): Immunofluorescent monoclonal antibodies against alphav int egrin were used to stain human preimplantation embryos. Main Outcome Measure(s): Immunofluorescence microscopy and computerized ima ge analysis were used to evaluate both qualitative and quantitative express ion of integrins in human embryos. Result(s): The alphav integrin subunit was found to be expressed in human e mbryos throughout their development (from two-cell stage up to blastocyst). The expression of alphav integrin subunit gradually increased throughout e mbryo development as measured quantitatively by image analysis. Conclusion(s): The expression of alphav integrin subunit throughout the dev elopment of preimplantation human embryos reinforces the concept of a role for integrins in the process of implantation. (C) 2001 by American Society for Reproductive Medicine.