Borna disease virus and human disease

Authors
Citation
Km. Carbone, Borna disease virus and human disease, CLIN MICROB, 14(3), 2001, pp. 513
Citations number
130
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Microbiology
Journal title
CLINICAL MICROBIOLOGY REVIEWS
ISSN journal
0893-8512 → ACNP
Volume
14
Issue
3
Year of publication
2001
Database
ISI
SICI code
0893-8512(200107)14:3<513:BDVAHD>2.0.ZU;2-Y
Abstract
mThe biology of Borna disease vints (BDV) strongly supports the likelihood of human infection with BDV or a variant of BDV. Thus far, the evidence sup porting BDV infection in humans has initiated much controversy among basic and clinical scientists; only time and additional research wilt support or refute the hypothesis of human BDV infection. Until an assay of acceptable specificity and sensitivity has been developed validated and used to docume nt human BDV infection, scientists cannot reasonably begin to associate BDV infection with specific disease syndromes. Clinical studies seeking causal associations between BDV infection and specific diseases must ensure the p roper identification of the BDV infection status of patients and control su bjects by using a validated, highly sensitive, and highly specific assay fo r series of assays). For clinical studies, a highly sensitive "screening" t est followed by a highly specific confirmatory test will be of significant benefit. Although it is possible to formulate hypotheses about the clinical outcomes of human BDV infection based on animal model work, to dare no hum an disease has been causally linked to human BDV infection. Scientists all over the world are actively pursuing these issues, and with continuing adva nces in clinical and basic BDV research, the answers cannot be far away.