The effect of acenocoumarol on hemorheological parameters

Citation
A. Vaya et al., The effect of acenocoumarol on hemorheological parameters, CL HEMORH M, 24(2), 2001, pp. 111-115
Citations number
15
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Hematology,"Cardiovascular & Hematology Research
Journal title
CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
ISSN journal
1386-0291 → ACNP
Volume
24
Issue
2
Year of publication
2001
Pages
111 - 115
Database
ISI
SICI code
1386-0291(2001)24:2<111:TEOAOH>2.0.ZU;2-#
Abstract
The effect of acenocoumarol on hemorheological variables was measured in 35 non-valvular chronic atrial fibrillation patients before starting oral ant icoagulant therapy (basal) and one and two months after beginning treatment (INR-2,3). Fibrinogen increased significantly from the basal situation: 33 2 +/- 99 mg/dl to 386 +/- 96 mg/dl in the second month (p < 0.05). However, this small increase in fibrinogen is not large enough to mediate other rhe ological changes, and whole blood filterability, blood viscosity, plasma vi scosity and erythrocyte deformability and aggregability remained unchanged after treatment. These results suggest that acenocoumarol does not affect r heological parameters and can therefore be used as a "neutral drug" for rhe ological studies in cardiovascular patients under oral anticoagulant therap y.