Changes in BiP (GRP78) levels upon HSV-1 infection are strain dependent

Citation
Hw. Mao et al., Changes in BiP (GRP78) levels upon HSV-1 infection are strain dependent, VIRUS RES, 76(2), 2001, pp. 127-135
Citations number
30
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Microbiology
Journal title
VIRUS RESEARCH
ISSN journal
0168-1702 → ACNP
Volume
76
Issue
2
Year of publication
2001
Pages
127 - 135
Database
ISI
SICI code
0168-1702(200108)76:2<127:CIB(LU>2.0.ZU;2-M
Abstract
BiP (grp78) is a chaperone protein which can also regulate the unfolded pro tein response of the cell. Levels of BiP increased in cells infected by the small plaque producing, cell associated, neuroinvasive strains of HSV-1 (S P7, 490) but decreased in cells infected with KOS, a Barge plaque, attenuat ed strain. BiP protein synthesis continued early in infection and BiP was s equestered and its degradation was limited during SP7 infection. BiP protei n synthesis stopped and the protein was degraded in KOS infected cells. The se viral strain dependent differences in BiP concentration may influence ot her aspects of the viral interaction with the target cell and its host. (C) 2001 Elsevier Science B.V. All rights reserved.