Cyclopia: a radiological and anatomical craniofacial post mortem study

Citation
C. Cannistra et al., Cyclopia: a radiological and anatomical craniofacial post mortem study, J CRAN MAX, 29(3), 2001, pp. 150-155
Citations number
15
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Dentistry/Oral Surgery & Medicine
Journal title
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
ISSN journal
1010-5182 → ACNP
Volume
29
Issue
3
Year of publication
2001
Pages
150 - 155
Database
ISI
SICI code
1010-5182(200106)29:3<150:CARAAC>2.0.ZU;2-4
Abstract
Cyclopia is a rare foetal malformation characterized by a single palpebral fissure and a proboscis associated with severe brain malformation, Approxim ately 1.05 in 100 000 births including stillbirths are identified as cyclop ian, Cyclopia is not compatible with Life. The authors present an anatomica l and histological study of the fronto-orbito-maxillary region carried out after 3-D CT reconstruction in a 21 week-old foetus with cyclopia, Anatomic al and histological observations suggest that the integrity of the trigemin al nerves is very important for the normal development of the embryological structures of the face, Fusion of the facial processes in the midline take s place even if central prosencephalic structures are absent. For this reas on the face in cyclopia, in both its positive and negative aspects, constit utes a model for the study of the normal development of this region. (C) 20 01 European Association for Cranio-Maxillofacial Surgery.