New method of derivatization and headspace solid-phase microextraction forgas chromatographic-mass spectrometric analysis of amphetamines in hair

Citation
Jt. Liu et al., New method of derivatization and headspace solid-phase microextraction forgas chromatographic-mass spectrometric analysis of amphetamines in hair, J CHROMAT B, 758(1), 2001, pp. 95-101
Citations number
12
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry & Analysis
Journal title
JOURNAL OF CHROMATOGRAPHY B
ISSN journal
1387-2273 → ACNP
Volume
758
Issue
1
Year of publication
2001
Pages
95 - 101
Database
ISI
SICI code
1387-2273(20010705)758:1<95:NMODAH>2.0.ZU;2-I
Abstract
A simple method for hair analysis of methamphetamine (MAMP) and amphetamine (AMP) by gas chromatography-mass spectrometry (GC-MS) was developed using simultaneous headspace solid-phase microextraction (HS-SPME) with derivatiz ation. After alkaline-digestion of hair, the analytes derivatized with hept afluoro-n-butyryl chloride were adsorbed on a polpdimethylsiloxane-coated f iber by HS-SPME and analyzed by GC-MS. Their mass spectra were, respectivel y, observable at 1 ng per sample. The standard curves in the range of 0.1-1 00 ng were linear. The intra-day coefficients of variation at each 0.5 ng w ere 12.5% for AMP and 3.8% for MAMP. The applicability of this method was d emonstrated in some case studies. (C) 2001 Elsevier Science B.V. All rights reserved.