Genetic analysis of a new mouse model for non-insulin-dependent diabetes

Citation
Jh. Kim et al., Genetic analysis of a new mouse model for non-insulin-dependent diabetes, GENOMICS, 74(3), 2001, pp. 273-286
Citations number
43
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Molecular Biology & Genetics
Journal title
GENOMICS
ISSN journal
0888-7543 → ACNP
Volume
74
Issue
3
Year of publication
2001
Pages
273 - 286
Database
ISI
SICI code
0888-7543(20010615)74:3<273:GAOANM>2.0.ZU;2-J
Abstract
The TallyHo (TH) mouse strain is a newly established model for non-insulin- dependent diabetes mellitus (NIDDM). TH mice show obesity, hyperinsulinemia , hyperlipidemia, and male-limited hyperglycemia. A genetic dissection of t he diabetes syndrome has been carried out using male backcross 1 progeny ob tained from crosses between (C57BL/6J x TH)F1 and TH mice or (CAST/Ei x TH) F1 and TH mice. A genome-wide scan reveals three quantitative trait loci (Q TLs), Tanidd1-3 (TH-associated NIDDM) linked to hyperglycemia. The major QT L (common in both crosses), Tanidd1, maps to chromosome (Chr) 19. Additiona lly, gene-gene interactions contributing to hyperglycemia have been observe d between Tanidd1 and a locus on Chr 18 as well as between Tanidd2 and a lo cus on Chr 16, The overt hyperglycemia in TH mice is, therefore, likely due to a mutation in a major diabetes susceptibility locus on Chr 19, which in teracts with additional genes to lead to an observable phenotype. (C) 2001 Academic Press.