New rat model for attention deficit hyperactive disorder (ADHD)

Citation
E. Kamimura et al., New rat model for attention deficit hyperactive disorder (ADHD), COMPAR MED, 51(3), 2001, pp. 245-251
Citations number
46
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Animal Sciences","Animal & Plant Sciences
Journal title
COMPARATIVE MEDICINE
ISSN journal
1532-0820 → ACNP
Volume
51
Issue
3
Year of publication
2001
Pages
245 - 251
Database
ISI
SICI code
1532-0820(200106)51:3<245:NRMFAD>2.0.ZU;2-M
Abstract
Purpose: In a strain of the Long-Evans Cinnamon (LEC) rats, we found sponta neously hyperactive animals designated as "wiggling," and established a con genic wiggling (Wig) rat by transferring the gene from the LEC to the Wista r King-Aptekman/Hokkaido (WKAH) strain. We evaluated the feasibility of the Wig rat for an animal model of human attention deficit hyperactive disorde r (ADHD). Methods: Mode of inheritance was examined by use of linkage analyses. Motor activity, behavior, and working memory were assessed by use of electric di gital counters, open field test, and Y-maze and water-maze tests. Results: The abnormal behavior, including hyperactivity, was transmitted in autosomal recessive mode. Diurnal and nocturnal motor activity of 12- to 1 4-week-old Wig rats was markedly higher than that of controls, and this hyp eractivity was more prominent during nighttime than daytime. Ambulation in the open-field test was significantly increased in Wig rats, but rearing wa s decreased in Wig rats, compared with controls. Results of the Y-maze test s indicated that spontaneous alternation behavior was significantly impaire d in Wig rats, although there was no difference in the total arm entries. T he water-maze test could not be performed because, when exposed to water, W ig rats panicked and almost drowned. Conclusions: Wig rats are hyperactive and have impaired working memory and impulsive behavior, as assessed by the motor activity and open-field tests and the Y-maze test, and these abnormalities are transmitted by a single ge ne with Mendelian pattern. Wig rats represent an excellent animal model of human ADHD.