Anti-HIV and cytotoxic activities of Ru(II)/Ru(III) polypyridyl complexes containing 2,6-(2 '-benzimidazolyl)-pyridine/chalcone as co-ligand

Citation
L. Mishra et al., Anti-HIV and cytotoxic activities of Ru(II)/Ru(III) polypyridyl complexes containing 2,6-(2 '-benzimidazolyl)-pyridine/chalcone as co-ligand, BIO MED CH, 9(7), 2001, pp. 1667-1671
Citations number
25
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY
ISSN journal
0968-0896 → ACNP
Volume
9
Issue
7
Year of publication
2001
Pages
1667 - 1671
Database
ISI
SICI code
0968-0896(200107)9:7<1667:AACAOR>2.0.ZU;2-1
Abstract
Ru(II)/Ru(III) polypyridyl complexes containing 2.6-(2'-benzimidazolyl)-pyr idine or chalcone as co-ligands were synthesized and characterized provious ly (Mishra, L.; Sinha, R. Indian J. Chem., Sec. A 2001, in press. Mishra. L .: Sinha, R. Indian J. Chem., Src. A, 39A, 2000, 1131). Their interaction w ith aqueous buffered calf thymus DNA was measured. (Novakova, O.; Kasparkov a, J., Vrana, O.: van Vliet. P. M., Reedijk. J.; Brabec, V, Biochem. 34, 19 95, 12369 and these results prompted additional screening for anti-HIV (hum an immunodeficiency virus) activity against DNA replication in H9 lymphocyt es and cytotoxic activity against eight tumor cell lines. The most active c ompounds were 17 in the former assay (EC50 < 0.1 <mu>g/mL and TI > 23.1) an d 3.8. 10, and 14 in the latter assay, especially selectively against the 1 A9 ovarian cancer cell line (IC50 = 4.1, 3.8, 3.6, and 2.5 mug/mL. respecti vely). (C) 2001 Elsevier Science Ltd. All rights reserved.