Deleterious effects of local corticosteroid injections on the Achilles tendon of rats

Citation
H. Tatari et al., Deleterious effects of local corticosteroid injections on the Achilles tendon of rats, ARCH ORTHOP, 121(6), 2001, pp. 333-337
Citations number
13
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Ortopedics, Rehabilitation & Sport Medicine
Journal title
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
ISSN journal
0936-8051 → ACNP
Volume
121
Issue
6
Year of publication
2001
Pages
333 - 337
Database
ISI
SICI code
0936-8051(200106)121:6<333:DEOLCI>2.0.ZU;2-#
Abstract
The purpose of this study was to examine the pathological changes in the Ac hilles tendon and its paratenon after intratendinous corticosteroid injecti ons and to reveal the effects of this drug on healthy tendon. We also sough t for the effects of these injections compared with compression with a clam p on the Achilles tendons of the rats. Fifty-two Achilles tendons in 26 mal e Wistar rats were included in the study. Betamethasone injections were app lied to the left tendons at different intervals, while the right tendons se rved for compression with mosquito clamps for varied periods. At the end of 30 days, all of the tendons were excised and examined histopathologically according to a semiquantitative scoring system. Histopathologic evaluation demonstrated some degree of degeneration in both groups. Statistical analys is showed no significant difference among the two groups, but in macroscopi c evaluation, the tendons in the betamethasone group demonstrated enlargeme nt and strong adhesion to the subcutaneous tissue. We conclude that intrate ndinous betamethasone injections are as harmful as compression with a clamp and can be used as a degeneration-producing model in further studies. Enla rgement of the tendon mass and strong adhesion to the subcutaneous tissue c an be due to injection of the betamethasone partly outside the tendon.