Modified seven-day, quadruple therapy as a first line Helicobacter pylori treatment

Citation
X. Calvet et al., Modified seven-day, quadruple therapy as a first line Helicobacter pylori treatment, ALIM PHARM, 15(7), 2001, pp. 1061-1065
Citations number
32
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology,"da verificare
Journal title
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
ISSN journal
0269-2813 → ACNP
Volume
15
Issue
7
Year of publication
2001
Pages
1061 - 1065
Database
ISI
SICI code
0269-2813(200107)15:7<1061:MSQTAA>2.0.ZU;2-#
Abstract
Background: Cure rates of 7-day triple therapy seem to be decreasing. Quadr uple therapies may be an alternative, although their complex administration makes patient acceptance difficult. Objective: To test the usefulness of a thrice a day, quadruple therapy to c ure Helicobacter pylori infection. Patients and methods: total of 122 consecutive patients with peptic ulcer a nd Helicobacter pylori infection were treated with omeprazole 20 mg b.d., t etracycline chlorhydrate 500 mg t.d.s., metronidazole 500 mg t.d.s., and bi smuth subcitrate 120 mg t.d.s. administered with meals for 7 days. Cure was tested by either endoscopy or breath test after 2 months, and by urea brea th test 6 months after therapy. Results: Seven patients were lost to follow-up. Of the remaining 115, 110 w ere cured at the first control, giving an intention-to-treat cure rate of 9 0.2% (95% CI: 83-95%) and a per protocol cure rate of 95.7% (95% CI: 90-98% ). One hundred three patients returned for a 6-month breath test; all but o ne were cured. Side-effects were minimal or minor in 47 patients (40.8%) an d moderate in four (3.4%). Compliance was good, 95% of patients taking more than 90% of the pills. Six (5%) patients stopped treatment after 1, 2, 4 ( two patients) and 6 (two patients) days. Conclusion: Thrice a day quadruple therapy shows excellent cure rates, far above 90%, is well-tolerated and compliance is easy. Head-to-head compariso n with triple therapies as first line Helicobacter pylori treatment seems w arranted.