Cure of Helicobacter pylori infection in elderly patients: comparison of low versus high doses of clarithromycin in combination with amoxicillin and pantoprazole

Citation
A. Pilotto et al., Cure of Helicobacter pylori infection in elderly patients: comparison of low versus high doses of clarithromycin in combination with amoxicillin and pantoprazole, ALIM PHARM, 15(7), 2001, pp. 1031-1036
Citations number
22
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology,"da verificare
Journal title
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
ISSN journal
0269-2813 → ACNP
Volume
15
Issue
7
Year of publication
2001
Pages
1031 - 1036
Database
ISI
SICI code
0269-2813(200107)15:7<1031:COHPII>2.0.ZU;2-J
Abstract
Background: Advancing age may influence clarithromycin's pharmacokinetics. No studies have yet compared the effects of different dosages of clarithrom ycin in combination with a proton pump inhibitor and amoxicillin in elderly patients. Aim: To compare the efficacy and tolerability of clarithromycin 250 mg vs. clarithromycin 500 mg twice daily (b.d.) in combination with pantoprazole a nd amoxicillin in elderly patients. Methods: One hundred and fifty-four elderly patients with H. pylori-associa ted ulcer disease or chronic gastritis were consecutively randomized to rec eive pantoprazole 40 mg daily plus amoxicillin 1 g, and either clarithromyc in 250 mg b.d, (PAC 250) or clarithromycin 500 mg b.d. (PAC 500). Two month s after therapy, endoscopy and gastric biopsies were repeated. Results: The cure rates of H. pylori infection in the PAC 250 and PAC 500 g roups were, respectively, 83% and 79% (ITT analysis) and 94% and 88% (PP an alysis) (P = N.S.). Significant decreases in chronic gastritis activity bot h in the body (P < 0.00001) and the antrum (P < 0.0001) of the stomach were found in H. pylori-cured patients, independently of clarithromycin dosage. Four patients in PAC 250 (5%) and seven in PAC 500 (9%) reported adverse e vents (P = N.S.). One patient in PAC 250 (25%) and three in PAC 500 (43%) d iscontinued the study because of these drug-related side-effects (P = N.S.) . Conclusions: In elderly patients, 1-week triple therapy with a proton pump inhibitor, amoxicillin and clarithromycin is a highly effective and well to lerated anti-H. pylori treatment. With this combination, clarithromycin at the lower dose of 250 mg b.d. achieved excellent cure rates and minimized a dverse events and costs.