Jhs. You et al., Economic analysis of four triple regimens for the treatment of Helicobacter pylori-related peptic ulcer disease in in-patient and out-patient settings in Hong Kong, ALIM PHARM, 15(7), 2001, pp. 1009-1015
Background: One-week triple regimens have been shown to be effective for th
e treatment of Helicobacter pylori-related peptic ulcer disease.
Aim: To conduct an economic analysis of four triple regimens for the treatm
ent of H. pylori-related peptic ulcer disease from the perspective of a pub
lic health organization in Hong Kong.
Methods: Records of 200 patients with H. pylori-related peptic ulcer diseas
e, who had previously participated in a randomized comparison of ranitidine
bismuth citrate (RBC) with amoxicillin and clarithromycin (RAC), omeprazol
e with amoxicillin and clarithromycin (OAC), RBC with metronidazole and tet
racycline (RMT), or, colloidal bismuth subcitrate with metronidazole and te
tracycline (BMT) in either in-patient or out-patient setting were reviewed.
Results: Fifty patients were excluded because of incomplete documentation o
r lack of peptic ulcer. In the out-patient group (n = 72), the median direc
t costs of the RAC group (HK $ 5094) were lower those of the BMT (HK $ 5400
), RMT (HK $ 5394), or OAC (HK $ 5440) groups, but the difference was signi
ficant only between the RAC and BMT groups (P < 0.05). In the in-patient gr
oup (n = 78), the median direct costs of the RMT group (HK $ 8524) were sig
nificantly lower than those of the OAC (HK $ 13 871) and RAC (HK $ 12 092)
groups (P < 0.05), but were similar to those of the BMT group (HK $ 8758).
Conclusions: RAC and RMT are the least costly regimens for out-patient and
in-patient treatment, respectively, of H. pylori-related peptic ulcer disea
se in Hong Kong.