Economic analysis of four triple regimens for the treatment of Helicobacter pylori-related peptic ulcer disease in in-patient and out-patient settings in Hong Kong

Citation
Jhs. You et al., Economic analysis of four triple regimens for the treatment of Helicobacter pylori-related peptic ulcer disease in in-patient and out-patient settings in Hong Kong, ALIM PHARM, 15(7), 2001, pp. 1009-1015
Citations number
11
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology,"da verificare
Journal title
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
ISSN journal
0269-2813 → ACNP
Volume
15
Issue
7
Year of publication
2001
Pages
1009 - 1015
Database
ISI
SICI code
0269-2813(200107)15:7<1009:EAOFTR>2.0.ZU;2-8
Abstract
Background: One-week triple regimens have been shown to be effective for th e treatment of Helicobacter pylori-related peptic ulcer disease. Aim: To conduct an economic analysis of four triple regimens for the treatm ent of H. pylori-related peptic ulcer disease from the perspective of a pub lic health organization in Hong Kong. Methods: Records of 200 patients with H. pylori-related peptic ulcer diseas e, who had previously participated in a randomized comparison of ranitidine bismuth citrate (RBC) with amoxicillin and clarithromycin (RAC), omeprazol e with amoxicillin and clarithromycin (OAC), RBC with metronidazole and tet racycline (RMT), or, colloidal bismuth subcitrate with metronidazole and te tracycline (BMT) in either in-patient or out-patient setting were reviewed. Results: Fifty patients were excluded because of incomplete documentation o r lack of peptic ulcer. In the out-patient group (n = 72), the median direc t costs of the RAC group (HK $ 5094) were lower those of the BMT (HK $ 5400 ), RMT (HK $ 5394), or OAC (HK $ 5440) groups, but the difference was signi ficant only between the RAC and BMT groups (P < 0.05). In the in-patient gr oup (n = 78), the median direct costs of the RMT group (HK $ 8524) were sig nificantly lower than those of the OAC (HK $ 13 871) and RAC (HK $ 12 092) groups (P < 0.05), but were similar to those of the BMT group (HK $ 8758). Conclusions: RAC and RMT are the least costly regimens for out-patient and in-patient treatment, respectively, of H. pylori-related peptic ulcer disea se in Hong Kong.