Review article: photodynamic therapy and the alimentary tract

Citation
Cr. Selvasekar et al., Review article: photodynamic therapy and the alimentary tract, ALIM PHARM, 15(7), 2001, pp. 899-915
Citations number
170
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Pharmacology,"da verificare
Journal title
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
ISSN journal
0269-2813 → ACNP
Volume
15
Issue
7
Year of publication
2001
Pages
899 - 915
Database
ISI
SICI code
0269-2813(200107)15:7<899:RAPTAT>2.0.ZU;2-P
Abstract
Photodynamic therapy offers the possibility of relatively selective tumour necrosis and normal tissue healing. It has many potential applications but as yet no clear role. Articles, editorials and case reports published prima rily in English and listed in Medline/ISI up to April 2000 or idenfied by a manual search have been reviewed in an attempt to provide a comprehensive overview of the use of photodynamic therapy in the alimentary tract. It is concluded that photodynamic therapy can be an effective treatment for superficial pre-malignant mucosal lesions and early cancers, especially in diffuse disease. Suitable patients include those wishing to avoid surgery, high risk subjects or those in whom other forms of treatment have failed. Superiority over other methods of ablation has not so far been demonstrated . Cheaper and more effective photosensitizers and improved techniques of li ght delivery are likely to increase the application of photodynamic therapy .