Nuclear receptors, coactivators and chromatin: new approaches, new insights

Authors
Citation
Kc. Lee et Wl. Kraus, Nuclear receptors, coactivators and chromatin: new approaches, new insights, TRENDS ENDO, 12(5), 2001, pp. 191-197
Citations number
69
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Endocrinology, Nutrition & Metabolism
Journal title
TRENDS IN ENDOCRINOLOGY AND METABOLISM
ISSN journal
1043-2760 → ACNP
Volume
12
Issue
5
Year of publication
2001
Pages
191 - 197
Database
ISI
SICI code
1043-2760(200107)12:5<191:NRCACN>2.0.ZU;2-O
Abstract
The actions of lipophilic hormones, including steroids, retinoids, thyroid hormone and vitamin D,, are mediated through a conserved superfamily of nuc lear receptor proteins that function as ligand-regulated, DNA-binding trans criptional activators in the chromatin environment of the nucleus. The liga nd-dependent transcriptional activity of nuclear receptors is enhanced by v arious cofactors that remodel chromatin, acetylate nucleosomal histones and contact the basal transcriptional machinery. The current challenge is to u nderstand the mechanistic details of how interactions among these factors e nhance transcription of hormone-regulated genes assembled into chromatin. C urrent biochemical and cell-based methods are providing some important clue s.