Characterization of a polymer-stabilized liposome system

Citation
N. Heldt et al., Characterization of a polymer-stabilized liposome system, REACT FUNCT, 48(1-3), 2001, pp. 181-191
Citations number
34
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
REACTIVE & FUNCTIONAL POLYMERS
ISSN journal
1381-5148 → ACNP
Volume
48
Issue
1-3
Year of publication
2001
Pages
181 - 191
Database
ISI
SICI code
1381-5148(20010502)48:1-3<181:COAPLS>2.0.ZU;2-V
Abstract
Polymer-stabilized liposome systems and non-polymer-stabilized (conventiona l) liposome systems were investigated for particle size, lipid association, micropolarity, and migration of a fluorescent probe between lipid bilayers . The size difference between the two types of liposome systems prepared wi th identical procedure was determined using light scattering method. NMR sp ectroscopic analysis using deuterium-labeled lipids showed that under the s et conditions all lipids in both polymer-stabilized and conventional liposo me systems become associated. Environmental micropolarity assessment of pyr ene showed that the probe localizes within the lipid bilayers of both polym er-stabilized and conventional liposome systems. Further investigation reve aled that the bilayers of both systems were mobile enough to permit migrati on of the probe into neighboring unlabeled liposome bilayers. (C) 2001 Publ ished by Elsevier Science B.V.