Molecular characterization of the klebicin B plasmid of Klebsiella pneumoniae

Citation
Ma. Riley et al., Molecular characterization of the klebicin B plasmid of Klebsiella pneumoniae, PLASMID, 45(3), 2001, pp. 209-221
Citations number
47
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Molecular Biology & Genetics
Journal title
PLASMID
ISSN journal
0147-619X → ACNP
Volume
45
Issue
3
Year of publication
2001
Pages
209 - 221
Database
ISI
SICI code
0147-619X(200105)45:3<209:MCOTKB>2.0.ZU;2-I
Abstract
The nucleotide sequence of a bacteriocin-encoding plasmid isolated from Kle bsiella pneumoniae (pKlebB-K17/80) has been determined. The encoded klebiei n B protein is similar in sequence to the DNase pyocins and colicins, sugge sting that klebiein B functions as a nonspecific endonuclease. The klebiein gene cluster, as well as the plasmid backbone. is a chimera, with regions similar to those of pore-former colicins, nuclease pyocins and colicins as well as noncolicinogenic plasmids. Similarities between pKlebB plasmid main tenance functions and those of the colicin El plasmid suggest that pKlebB i s a member of the ColE1 plasmid replication family. (C) 2001 Academic Press