Expression of heparin binding epidermal growth factor-like growth factor in hepatocellular carcinoma: An immunohistochemical study

Citation
Y. Ito et al., Expression of heparin binding epidermal growth factor-like growth factor in hepatocellular carcinoma: An immunohistochemical study, ONCOL REP, 8(4), 2001, pp. 903-907
Citations number
16
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Oncology
Journal title
ONCOLOGY REPORTS
ISSN journal
1021-335X → ACNP
Volume
8
Issue
4
Year of publication
2001
Pages
903 - 907
Database
ISI
SICI code
1021-335X(200107/08)8:4<903:EOHBEG>2.0.ZU;2-5
Abstract
Previous studies have demonstrated an elevated level of heparin-binding epi dermal growth factor-like growth factor (HB-EGF) mRNA in hepatocarcinogenes is in a rodent model and of its protein as well as mRNA in human hepatocell ular carcinoma (HCC). In order to elucdiate the clinical significance of HB -EGF in human HCC, we immunohistochemically investigated its expression in 100 HCC cases with different characteristics. HB-EGF was not or only faintl y expressed in non-cancerous hepatocytes. On the other hand, 59% of the HCC cases were classified as positive for HB-EGF and its expression was more f requently observed in cases with low proliferating activity, at an early st age, of small size, without portal invasion, low alpha -fetoprotein level, without: satellite nodules (borderline significance), and well or moderate differentiation. Furthermore, HB-EGF expression showed prognostic significa nce in both univariate and multivariate analyses and can be regarded as an independent prognostic factor of disease-free survival. These results stron gly suggest the involvement of HB-EGF in early stage of HCC.