Expression of thrombospondin-1 inversely correlated with tumor vascularityand hematogenous metastasis in colon cancer

Citation
K. Maeda et al., Expression of thrombospondin-1 inversely correlated with tumor vascularityand hematogenous metastasis in colon cancer, ONCOL REP, 8(4), 2001, pp. 763-766
Citations number
17
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Oncology
Journal title
ONCOLOGY REPORTS
ISSN journal
1021-335X → ACNP
Volume
8
Issue
4
Year of publication
2001
Pages
763 - 766
Database
ISI
SICI code
1021-335X(200107/08)8:4<763:EOTICW>2.0.ZU;2-L
Abstract
Solid tumors require neovascularization for growth and metastasis. Angiogen esis depends on the local balance between various molecules that induce and inhibit neovascularization. Thrombospondin-1 (TSP-1) is thought to be an a ntiangiogenic factor. In this study, we examined the correlation between ex pression of TSP-1 and tumor vascularity, and determined its prognostic sign ificance in colon cancer. Microvessel density, determined by immunostaining for factor VIII-related antigen, was significantly higher in tumors that w ere TSP-1-negative. TSP-1 expression was inversely correlated with prognosi s. Patients with TSP-1-negative tumors had a significantly worse prognosis than did those with TSP-1-positive tumors, Frequency of hepatic recurrence was significantly higher in patients with tumors that were TSP-1-negative. In conclusion, TSP-1 is an important negative regulator of tumor angiogenes is, and TSP-1 may be useful for predicting recurrence in patients with colo n cancer.