Expression of thymidylate synthase in cancer of the ampulla of Vater

Citation
T. Ajiki et al., Expression of thymidylate synthase in cancer of the ampulla of Vater, ONCOL REP, 8(4), 2001, pp. 759-762
Citations number
20
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Oncology
Journal title
ONCOLOGY REPORTS
ISSN journal
1021-335X → ACNP
Volume
8
Issue
4
Year of publication
2001
Pages
759 - 762
Database
ISI
SICI code
1021-335X(200107/08)8:4<759:EOTSIC>2.0.ZU;2-5
Abstract
The clinical and therapeutic significance of thymidylate synthase (TS) in c ancers of the ampulla of Vater have not yet been reported. We immunohistoch emically evaluated TS expression in 33 ampullary cancers using an anti-TS a ntibody. TS expression, clinicopathologic variables, and survival rates wer e examined and the correlations between these parameters were identified. F ifteen patients were found to express high levels of TS (high TS group), wh ile 18 patients expressed low levels of TS (low TS group). No significant d ifference was found between TS expression and clinicopathologic factors. Un ivariate and multivariate analysis revealed that lymph node metastasis and pancreatic invasion are important variables for independently predicting po stoperative survival. Although TS expression was not identified as an impor tant factor for postoperative survival, recurrent cases in patients with ch emotherapy existed only in the high TS group. In the present: study, it was found that TS expression itself in cancers of the ampulla of Vater has no impact in predicting the prognosis of ampullary cancers, but a chemotherape utic benefit of evaluating TS expression may exist.