Thymidine phosphorylase expression and effect of doxifluridine: A phase IIstudy

Citation
S. Sadahiro et al., Thymidine phosphorylase expression and effect of doxifluridine: A phase IIstudy, ONCOL REP, 8(4), 2001, pp. 753-758
Citations number
30
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Oncology
Journal title
ONCOLOGY REPORTS
ISSN journal
1021-335X → ACNP
Volume
8
Issue
4
Year of publication
2001
Pages
753 - 758
Database
ISI
SICI code
1021-335X(200107/08)8:4<753:TPEAEO>2.0.ZU;2-U
Abstract
Doxifluridine (5 ' -DFUR), an active intermediate metabolite of capecitabin e, is converted to 5-fluorouracil by thymidine phosphorylase (TP). We used immunohistochemical staining to investigate the relation between TP express ion and 5 ' -DFUR effects in 40 patients with advanced/recurrent lung metas tases from colorectal cancer. Cox regression analysis suggested that TP-pos itive cancer cells (risk ratio 3.72), were independent factors in survival whereas factors in progression-free survival were TP-positive cancer cells (2.93), and TF-positive stromal cells (0.24). It is suggested that TP expre ssion in cancer cells and in stromal cells are opposite prognostic factors in patients treated with 5 ' -DFUR.