Oestrogen, its receptors and function in the male reproductive tract - a review

Citation
Ra. Hess et al., Oestrogen, its receptors and function in the male reproductive tract - a review, MOL C ENDOC, 178(1-2), 2001, pp. 29-38
Citations number
90
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Endocrinology, Nutrition & Metabolism
Journal title
MOLECULAR AND CELLULAR ENDOCRINOLOGY
ISSN journal
0303-7207 → ACNP
Volume
178
Issue
1-2
Year of publication
2001
Pages
29 - 38
Database
ISI
SICI code
0303-7207(20010610)178:1-2<29:OIRAFI>2.0.ZU;2-O
Abstract
Oestrogen is synthesized in the male reproductive system by at least three different cell types; Sertoli, Leydig and germ cells. Although testosterone is recognized as the primary sex steroid in man, oestrogen is produced in sizable quantities in the testis. as well as the brain and is found in extr emely high concentrations in the semen of several species. The high concent ration of oestrogen in rete testis fluid of the rodent is now thought to be derived from the conversion of testosterone to estradiol by P450 aromatase in germ cells of the testis and spermatozoa traversing the reproductive tr act. This new major source of oestrogen would target oestrogen receptors in the male reproductive tract, in particular the efferent ductules, which co ntain the highest concentration of oestrogen receptor-alpha. This recent da ta raises new hypotheses regarding the role of oestrogen in the function of the male reproductive system. The oestrogen receptor-alpha knockout mouse was used to help define the function of oestrogen in the male. It was found that oestrogen receptor-alpha is essential for fluid reabsorption in the e fferent ductules and in the absence of expression the male is infertile. (C ) 2001 Elsevier Science Ireland Ltd. All rights reserved.