Annotated draft genomic sequence from a Streptococcus pneumoniae type 19F clinical isolate

Citation
J. Dopazo et al., Annotated draft genomic sequence from a Streptococcus pneumoniae type 19F clinical isolate, MICROB DR R, 7(2), 2001, pp. 99-125
Citations number
25
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Clinical Immunolgy & Infectious Disease",Microbiology
Journal title
MICROBIAL DRUG RESISTANCE-MECHANISMS EPIDEMIOLOGY AND DISEASE
ISSN journal
1076-6294 → ACNP
Volume
7
Issue
2
Year of publication
2001
Pages
99 - 125
Database
ISI
SICI code
1076-6294(200122)7:2<99:ADGSFA>2.0.ZU;2-A
Abstract
The public availability of numerous microbial genomes is enabling the analy sis of bacterial biology in great detail and with an unprecedented, organis m-wide and taxon-wide, broad scope. Streptococcus pneumoniae is one of the most important bacterial pathogens throughout the world. We present here se quences and functional annotations for 2.1-Mbp of pneumococcal DNA, coverin g more than 90% of the total estimated size of the genome. The sequenced st rain is a clinical isolate resistant to macrolides and tetracycline. It car ries a type 19F capsular locus, but multilocus sequence typing for several conserved genetic loci suggests that the strain sequenced belongs to a pneu mococcal lineage that most often empresses a serotype 15 capsular polysacch aride. A total of 2,046 putative open reading frames (ORFs) longer than 100 amino acids were identified (average of 1,009 bp per ORF), including all d escribed two-component systems and aminoacyl tRNA synthetases. Comparisons to other complete, or nearly complete, bacterial genomes were made and are presented in a graphical form for all the predicted proteins.