Influence of various hemodialysis membranes on the plasma (1 -> 3)-beta-D-glucan level

Citation
H. Kanda et al., Influence of various hemodialysis membranes on the plasma (1 -> 3)-beta-D-glucan level, KIDNEY INT, 60(1), 2001, pp. 319-323
Citations number
15
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Urology & Nephrology","da verificare
Journal title
KIDNEY INTERNATIONAL
ISSN journal
0085-2538 → ACNP
Volume
60
Issue
1
Year of publication
2001
Pages
319 - 323
Database
ISI
SICI code
0085-2538(200107)60:1<319:IOVHMO>2.0.ZU;2-L
Abstract
Background. Recently. invasive fungal infections have increased significant ly because of the growing number of immunocompromised hosts. The measuremen t of plasma (1 -->3)-beta -D-glucan has been proposed as a useful diagnosti c tool for deep mycosis. In this study. we analyzed the alteration of the p lasma (1 -->3)-beta -D-glucan concentration by using different kinds of hem odialvsis (HD) membranes in end-stage renal disease (ESRD) patients and est imated its half-life. Methods. Twenty-seven patients with ESRD without known fungal infections (w ith a median age of 66 years old) were enrolled in this study. Cellulose tr iacetate (CTA) membrane, cellulose (Cu) membrane, and polymethyl methacryla te (PMMA) membrane were used in three consecutive initiations of HD and pla sma (1 -->3)-beta -D-glucan concentration was measured before and after eac h HD session. Results. The level did not change between before and after HD when CTA and PMMA membranes were used. In contrast, the plasma (1 -->3)-beta -D-glucan l evel increased greatly after HD using the Cu membrane (from 9.4 to 332 pg/m L in median). Hypothesizing that the plasma (1 -->3)-beta -D-glucan level d eclines exponentially. its median half-life is estimated at 20 hours, which is not affected by hepatic or renal function. Conclusions. Because the plasma (1 -->3)-beta -D-glucan level increases dra matically after HD using the Cu membrane. dialyzers with Cu membrane should be avoided for HD in patients with suspected deep mycosis. The measurement of plasma (1 -->3)-beta -D-glucan is also useful For the patients with hep atic or renal Failure.