Neoclerodane diterpenoids from Scutellaria caerulea

Citation
B. Esquivel et al., Neoclerodane diterpenoids from Scutellaria caerulea, J NAT PROD, 64(6), 2001, pp. 778-782
Citations number
22
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
0163-3864 → ACNP
Volume
64
Issue
6
Year of publication
2001
Pages
778 - 782
Database
ISI
SICI code
0163-3864(200106)64:6<778:NDFSC>2.0.ZU;2-Z
Abstract
Five new neoclerodane diterpenoids have been isolated from Scutellaria caer ulea: (11S*)-6 alpha -acetoxy-7 beta ,11-diisobutiryloxy-1 beta ,8 beta -di hydroxy-4(18),13-neoclerodadien-15,16-olide (scuterulein A) (1); (13R*)-1 b eta -6 alpha -7 beta -triacetoxy-11 betap-benzoyloxy-8 beta ,13-epoxy-4(18) -neoclerodadien-15,16-olide (scuterulein B) (2); (11S*)-1 beta ,6 alpha, 11 -triacetoxy-7 beta -isobutiryloxy-8 beta -hydrox-4(18),13-neoclerodadien-15 ,16-olide (scuterulein C) (3); (11S*)-6 alpha ,11-diacetoxy-7 beta -isobuti ryloxy-1 beta ,8 beta -dihydroxy-4(18),13 -neoclerodadien-15, 16-olide (dea cetyl scuterulein C) (4), and (11E)-6 alpha -acetoxy-7 beta -isobutiryloxy- 1 beta ,8 beta -dihydroxy-4(18),11,13-neoclerodatrien-15,16- olide (scuteru lein D) (5). Structures were established by spectroscopic and chemical meth ods. An X-ray analysis was carried out on scuterulein B (2).